Hadron Collider Sensitivity to Fat Flavourful Z′Z^\primes for RK(∗)R_{K^{(\ast)}}

We further investigate the case where new physics in the form of a massive $Z^\prime$ particle explains apparent measurements of lepton flavour non-universality in $B \rightarrow K^{(\ast)} l^+ l^-$ decays. Hadron collider sensitivities for direct production of such $Z^\prime$s have been previously studied in the narrow width limit for a $\mu^+ \mu^-$ final state. Here, we extend the analysis to sizeable decay widths and improve the sensitivity estimate for the narrow width case. We estimate the sensitivities of the high luminosity 14 TeV Large Hadron Collider (HL-LHC), a high energy 27 TeV LHC (HE-LHC), as well as a potential 100 TeV future circular collider (FCC). The HL-LHC has sensitivity to narrow $Z^\prime$ resonances consistent with the anomalies. In one of our simplified models the FCC could probe 23 TeV $Z^\prime$ particles with widths of up to 0.35 of their mass at 95\% confidence level (CL). In another model, the HL-LHC and HE-LHC cover sizeable portions of parameter space, but the whole of perturbative parameter space can be covered by the FCC.Comment: 24 pages, 11 figures; v2 Reference

Constraining anomalous Higgs interactions

The recently announced Higgs discovery marks the dawn of the direct probing of the electroweak symmetry breaking sector. Sorting out the dynamics responsible for electroweak symmetry breaking now requires probing the Higgs interactions and searching for additional states connected to this sector. In this work we analyze the constraints on Higgs couplings to the standard model gauge bosons using the available data from Tevatron and LHC. We work in a model--independent framework expressing the departure of the Higgs couplings to gauge bosons by dimension--six operators. This allows for independent modifications of its couplings to gluons, photons and weak gauge bosons while still preserving the Standard Model (SM) gauge invariance. Our results indicate that best overall agreement with data is obtained if the cross section of Higgs production via gluon fusion is suppressed with respect to its SM value and the Higgs branching ratio into two photons is enhanced, while keeping the production and decays associated to couplings to weak gauge bosons close to their SM prediction.Comment: v3: Added acknowledgment to FP7 ITN INVISIBLES (Marie Curie Actions PITN-GA-2011-289442). Nothing else changed with respect to v

Timed Consistent Network Updates

Network updates such as policy and routing changes occur frequently in Software Defined Networks (SDN). Updates should be performed consistently, preventing temporary disruptions, and should require as little overhead as possible. Scalability is increasingly becoming an essential requirement in SDN. In this paper we propose to use time-triggered network updates to achieve consistent updates. Our proposed solution requires lower overhead than existing update approaches, without compromising the consistency during the update. We demonstrate that accurate time enables far more scalable consistent updates in SDN than previously available. In addition, it provides the SDN programmer with fine-grained control over the tradeoff between consistency and scalability.Comment: This technical report is an extended version of the paper "Timed Consistent Network Updates", which was accepted to the ACM SIGCOMM Symposium on SDN Research (SOSR) '15, Santa Clara, CA, US, June 201

Systems biology analysis of drivers underlying hallmarks of cancer cell metabolism.

Malignant transformation is often accompanied by significant metabolic changes. To identify drivers underlying these changes, we calculated metabolic flux states for the NCI60 cell line collection and correlated the variance between metabolic states of these lines with their other properties. The analysis revealed a remarkably consistent structure underlying high flux metabolism. The three primary uptake pathways, glucose, glutamine and serine, are each characterized by three features: (1) metabolite uptake sufficient for the stoichiometric requirement to sustain observed growth, (2) overflow metabolism, which scales with excess nutrient uptake over the basal growth requirement, and (3) redox production, which also scales with nutrient uptake but greatly exceeds the requirement for growth. We discovered that resistance to chemotherapeutic drugs in these lines broadly correlates with the amount of glucose uptake. These results support an interpretation of the Warburg effect and glutamine addiction as features of a growth state that provides resistance to metabolic stress through excess redox and energy production. Furthermore, overflow metabolism observed may indicate that mitochondrial catabolic capacity is a key constraint setting an upper limit on the rate of cofactor production possible. These results provide a greater context within which the metabolic alterations in cancer can be understood

A kinetic Monte Carlo method for the atomic-scale simulation of chemical vapor deposition: Application to diamond

We present a method for simulating the chemical vapor deposition (CVD) of thin films. The model is based upon a three-dimensional representation of film growth on the atomic scale that incorporates the effects of surface atomic structure and morphology. Film growth is simulated on lattice. The temporal evolution of the film during growth is examined on the atomic scale by a Monte Carlo technique parameterized by the rates of the important surface chemical reactions. The approach is similar to the N-fold way in that one reaction occurs at each simulation step, and the time increment between reaction events is variable. As an example of the application of the simulation technique, the growth of {111}-oriented diamond films was simulated for fifteen substrate temperatures ranging from 800 to 1500 K. Film growth rates and incorporated vacancy and H atom concentrations were computed at each temperature. Under typical CVD conditions, the simulated growth rates vary from about 0.1 to 0.8 μm/hr between 800 and 1500 K and the activation energy for growth on the {111}: H surface between 800 and 1100 K is 11.3 kcal/mol. The simulations predict that the concentrations of incorporated point defects are low at substrate temperatures below 1300 K, but become significant above this temperature. If the ratio between growth rate and point defect concentration is used as a measure of growth efficiency, ideal substrate temperatures for the growth of {111}-oriented diamond films are in the vicinity of 1100 to 1200 K. © 1997 American Institute of Physics.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/70750/2/JAPIAU-82-12-6293-1.pd